Full text NHG Guideline on Subfertility (pdf)

Download free summary card (pdf)


The NHG Guideline subfertility provides recommendations for diagnosis and management in the event of a desired pregnancy failing to occur. Subfertility is defined as the absence of pregnancy after more than twelve months of unprotected intercourse aimed at achieving conception.

Management of subfertility depends on the history and findings from physical examination and additional examination. The chance of pregnancy strongly depends on the age of the woman and the quality of the sperm. In order to estimate the chance of a pregnancy in the next year a prediction model is used in the guideline.

The guideline also includes a section on guidance of couples with long-term subfertility problems.


The guideline program of the College is designed for GPs in the context of the Dutch healthcare system. It makes no warranties concerning the efficacy of the guidelines used in other countries. The information is for educational and/or professional use only and is provided in good faith without any express or implied warranty. The College does not accept responsibility for any loss or damage occasioned by use of the information contained on the website nor from any access to the website. All access and use is at the risk of the end-user.

Additional information


Van Asselt KM, Hinloopen RJ, Silvius AM, Van der Linden PJQ, Van Oppen CCAN, Van Balen JAM



Revision Date

April 2010